NAD+ Therapy - Anti-Aging & Cellular Regeneration
Simon Med Spa
Simon Lee, MD
Aesthetics located in Milpitas, CA & Burlingame, CA
NAD+ Therapy - Anti-Aging & Cellular Regeneration
NAD+ Therapy - Anti-Aging & Cellular Regeneration
NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme present in every cell, essential for energy production, DNA repair, and cellular longevity. With age, NAD+ levels decline by up to 50% by middle age, contributing to aging and metabolic dysfunction. NAD+ therapy delivers direct intravenous infusion or oral/sublingual formulations to restore youthful cellular function.
Key Benefits
✔ Boosts Cellular Energy: Enhances mitochondrial ATP production
✔ DNA Repair Activation: Supports sirtuin proteins (SIRT1-7) for genomic stability
✔ Anti-Aging Effects: Shown to extend lifespan in preclinical studies
✔ Neuroprotection: May improve cognitive function and reduce neurodegeneration risk
Science Behind NAD+
1. Mitochondrial Fuel: Critical for electron transport chain (ETT) in ATP synthesis
2. Sirtuin Activation: Regulates longevity pathways (e.g., FOXO, p53)
3. Metabolic Support: Improves insulin sensitivity and lipid metabolism
Clinical Applications
▶ Anti-Aging: Skin rejuvenation, muscle preservation
▶ Neurological: Alzheimer’s/Parkinson’s support (investigational)
▶ Metabolic: Obesity, type 2 diabetes adjunct therapy
▶ Addiction Recovery: Reduces withdrawal symptoms (FDA-approved for alcohol dependence)
Delivery Methods
▸ IV Infusion: 100-500mg doses (30-90 min sessions) for immediate bioavailability
▸ Oral/Sublingual: NR (Nicotinamide Riboside) or NMN supplements
▸ Intramuscular: Lower-dose maintenance therapy
Treatment Protocol
• Initial Phase: 4-6 IV sessions over 2-3 weeks
• Maintenance: Monthly infusions or daily NR/NMN (250-1000mg)
Safety:
• Generally well-tolerated
• Mild flushing/nausea possible during IV administration
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